의학 통풍치료제-레시누라드(lesinurad)

의학 통풍치료제-레시누라드(lesinurad)

[의학] 통풍치료제-레시누라드(lesinurad).pptx

목차 1.INTRODUCTION -What is gout -How to treat -Cause / Drug of gout 2.DRUG INFORMATION -Lesinurad as a URAT1 inhibitor 3.CLINICAL TRIAL 본문 WHAT IS GOUT Gout caused by abnormally elevated levels of uric acid  in the blood (sUA *> 6.8mg/dL ) resulting in a build-up uric acid crystals throughout the body * sUA :serum uric acid Hyperuricemia linked to elevated hypertension in adults and children increased mortality in Chronic Kidney Disease and possibly other cardiovascular risk factors, including elevated C-Reactive Protein Increasing incidence and severity in US approximately 8 million patients HOW TO TREAT Two goals for treatment of hyperuricemia /gout Acute treatment for inflammation NSAIDS , colchicine, corticosteroid, IL 1 inhibitor Chronic treatment to lower serum uric acid Uricosurics : benzobromarone , probenecid, sulfinpyrazone Xanthine oxidase inhibitors : allopurinol, febuxostat (FBX) Uricase : pegloticase 참고문헌 Ardea Biosciences Reports Positive Results for RDEA594, its Lead Product Candidate for Gout, in Combination with Allopurinol or Febuxostat, January 2010 Ken Okamoto and Takeshi Nishino, Crystral structures of mammalian xanthine oxidoreductase bound with various inhibitor: allopurinol, febuxostat, and FYX-051 L-T.Yeh 외 8명, Safety, phamacokinetics, and serum uric acid lowering effect of RDEA594, a novel uricosuric agent, in healthy volunteers, June 10, 2009 Z.shen 외 9명, Lesinurad , A novel URAT1 Inhibitor, Shows Additive Serum Urate Lowring Effecrs in Combination with Xanthine Oxidase Inhibitor Febuxostat X Yang 외 7명, Evaluation of drug-drug interacion potential between RDEA594, Allopurinol and Febuxostat in preclinical species, October 16, 2009 Sasha B. Coffiner, Ardea seeks partner for RDEA 594 in gout, executive says; may be effective in combination with febuxustat, allopurinol rheumatologists, July 2, 2010 R. Fleischmann 외 9명, Lesinurad (RDEA594), A Novel Oral Uricosuric Agent, in combination with Febuxostat Shows Significant Additive Urate Lowering Effects in Gout Subjects with 100% Response Achieved for All Combination Dose Regimens, May 25, 2011 키워드 통풍콩제, 레시누라드, 콩제, lesinurad, 통풍