의약 의약품 화학 실험-CCR5 antagonists

의약 의약품 화학 실험-CCR5 antagonists

[의약] 의약품 화학 실험-CCR5 antagonists.pptx

목차 CCR5 CCR5 antagonist Drug development SAR New drug design 본문 CCR5 C-C chemokine receptor type 5, also known as CCR5 or CD195 protein on the surface of white blood cells that is involved in the immune system the process by which T cells are attracted to specific tissue and organ targets Many forms of HIV, the virus that causes AIDS, initially use CCR5 to enter and infect host cells CCR5의 기능 belongs to the beta chemokine receptors family of integral membrane proteins. G protein-coupled receptor The natural chemokine ligands : RANTES and MIP 1α and 1β .It also interacts with CCL3L1. T cells, macrophages, dendritic cells and microglia inflammatory responses to infection